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Secretin family of 7 transmembrane receptors is a family of evolutionarily related proteins.[1]

This family is known as Family B, the secretin-receptor family or family 2 of the G-protein-coupled receptors.They have been described in many animal species, but not in plants, fungi or prokaryotes. Three distinct sub-families (B1-B3) are recognized. Many secretin receptors are regulated by peptide hormoness from the glucagon hormone family.

The secretin-like GPCRs include secretin, calcitonin, parathyroid hormone/parathyroid hormone-related peptides and vasoactive intestinal peptide receptors, all of which activate adenylyl cyclase and the phosphatidyl-inositol-calcium pathway. These receptors have 7 transmembrane helices, like rhodopsin-like GPCRs. However,there is no significant sequence identity between these families: the secretin-like receptors thus bear their own unique '7TM' signature.

Subfamily B1

Subfamily B1 contains classical hormone receptors, such as receptors for secretin and glucagon, that are all involved in cAMP-mediated signalling pathways.

  • Adenylate cyclase-activating type 1 receptor, pituitary Template:InterPro
    • ADCYAP1R1
  • Calcitonin receptor Template:InterPro
  • Corticotropin-releasing hormone receptor Template:InterPro
    • CRHR1; CRHR2
  • Glucagon receptor-related Template:InterPro
  • Growth hormone releasing hormone receptor Template:InterPro
    • GHRHR
  • Parathyroid hormone receptor Template:InterPro
    • PTHR1; PTHR2
  • Secretin receptor Template:InterPro
    • SCTR
  • Vasoactive intestinal peptide receptor Template:InterPro
    • VIPR1; VIPR2

Subfamily B2

Subfamily B2 contains receptors with long extracellular N-termini, such as the leukocyte cell-surface antigen CD97; calcium-independent receptors for latrotoxin (such as UniProt O94910, and brain-specific angiogenesis inhibitor receptors (such as UniProt O14514) amongst others.

  • Brain-specific angiogenesis inhibitor Template:InterPro
    • BAI1; BAI2; BAI3
  • CD97 antigen Template:InterPro
    • CD97
  • EMR hormone receptor Template:InterPro
  • Gastric inhibitory polypeptide receptor Template:InterPro
    • GCGR; GIPR
  • GPR56 orphan receptor Template:InterPro
    • GPR56; GPR64; GPR97; GPR110; GPR111; GPR112; GPR113; GPR114; GPR115; GPR123; GPR125; GPR126; GPR128; GPR133; GPR144; GPR157
  • Latrophilin receptor Template:InterPro
    • ELTD1; LPHN1; LPHN2; LPHN3

Subfamily B3

Subfamily B3 includes Methuselah and other Drosophila proteins. Other than the typical seven-transmembrane region, characteristic structural features include an amino-terminal extracellular domain involved in ligand binding, and an intracellular loop (IC3) required for specific G-protein coupling.

  • Diuretic hormone receptor Template:InterPro

Unclassified subfamilies

  • Ig-hepta receptor Template:InterPro
    • GPR116

Unclassified members

DREG; HCTR-5; HCTR-6; KPG_003; KPG_006; KPG_008; KPG_009; RESDA1


  1. Harmar AJ (2001). Family-B G-protein-coupled receptors. Genome Biol. 2 (12): REVIEWS3013.
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