Psychology Wiki

Assessment | Biopsychology | Comparative | Cognitive | Developmental | Language | Individual differences | Personality | Philosophy | Social |
Methods | Statistics | Clinical | Educational | Industrial | Professional items | World psychology |

Biological: Behavioural genetics · Evolutionary psychology · Neuroanatomy · Neurochemistry · Neuroendocrinology · Neuroscience · Psychoneuroimmunology · Physiological Psychology · Psychopharmacology (Index, Outline)

Selenium (pronounced /səˈliːniəm/) is a chemical element with atomic number 34, with the chemical symbol Se. It is a nonmetal, chemically related to sulfur and tellurium, and rarely occurring in its elemental state in nature. It is toxic in large amounts, but trace amounts of it are necessary for cellular function in most, if not all, animals, forming the active center of the enzymes glutathione peroxidase and thioredoxin reductase (which indirectly reduce certain oxidized molecules in animals and some plants) and three known deiodinase enzymes (which convert one thyroid hormone to another). Selenium requirements in plants differ by species, with some plants apparently requiring none.[1]

Isolated selenium occurs in several different forms, the most stable of which is a dense purplish-gray semimetal (semiconductor) form that is structurally a trigonal polymer chain. It conducts electricity better in the light than in the dark, and is used in photocells (see allotropic section below). Selenium also exists in many nonconductive forms: a black glass-like allotrope, as well as several red crystalline forms built of eight-membered ring molecules, like its lighter chemical cousin sulfur.

Selenium is found in economic quantities in sulfide ores such as pyrite, partially replacing the sulfur in the ore matrix. Minerals that are selenide or selenate compounds are also known, but all are rare.


Selenium occurs naturally in a number of inorganic forms, including selenide, selenate and selenite. In soils, selenium most often occurs in soluble forms like selenate (analogous to sulfate), which are leached into rivers very easily by runoff.

Selenium has a biological role, and is found in organic compounds such as dimethyl selenide, selenomethionine, selenocysteine and methylselenocysteine. In these compounds selenium plays an analogous role to sulfur.

Selenium is most commonly produced from selenide in many sulfide ores, such as those of copper, silver, or lead. It is obtained as a byproduct of the processing of these ores, from the anode mud of copper refineries and the mud from the lead chambers of sulfuric acid plants. These muds can be processed by a number of means to obtain free selenium.

Natural sources of selenium include certain selenium-rich soils, and selenium that has been bioconcentrated by certain toxic plants such as locoweed. Anthropogenic sources of selenium include coal burning and the mining and smelting of sulfide ores.[2]

See also Selenide minerals.


Main article: isotopes of selenium

Selenium has six naturally occurring isotopes, five of which are stable: 74Se, 76Se, 77Se, 78Se, and 80Se. The last three also occur as fission products, along with 79Se which has a halflife of 295,000 years, and 82Se which has a very long half life (~1020 yr, decaying via double beta decay to 82Kr) and for practical purposes can be considered to be stable. 23 other unstable isotopes have been characterized.

History and global demand

Selenium (Greek σελήνη selene meaning "Moon") was discovered in 1817 by Jöns Jakob Berzelius who found the element associated with tellurium (named for the Earth).

Growth in selenium consumption was historically driven by steady development of new uses, including applications in rubber compounding, steel alloying, and selenium rectifiers. By 1970, selenium in rectifiers had largely been replaced by silicon, but its use as a photoconductor in plain paper copiers had become its leading application. During the 1980s, the photoconductor application declined (although it was still a large end-use) as more and more copiers using organic photoconductors were produced. Presently, the largest use of selenium world-wide is in glass manufacturing, followed by uses in chemicals and pigments. Electronic use, despite a number of continued applications, continues to decline.[3]

In 1996, continuing research showed a positive correlation between selenium supplementation and cancer prevention in humans, but widespread direct application of this important finding would not add significantly to demand owing to the small doses required. In the late 1990s, the use of selenium (usually with bismuth) as an additive to plumbing brasses to meet no-lead environmental standards, became important. At present, total world selenium production continues to increase modestly.

Selenium and health

Although it is toxic in large doses, selenium is an essential micronutrient for animals. In plants, it occurs as a bystander mineral, sometimes in toxic proportions in forage (some plants may accumulate selenium as a defense against being eaten by animals, but other plants such as locoweed require selenium, and their growth indicates the presence of selenium in soil).[4] It is a component of the unusual amino acids selenocysteine and selenomethionine. In humans, selenium is a trace element nutrient which functions as cofactor for reduction of antioxidant enzymes such as glutathione peroxidases and certain forms of thioredoxin reductase found in animals and some plants (this enzyme occurs in all living organisms, but not all forms of it in plants require selenium).

Glutathione peroxidase (GSH-Px) catalyzes certain reactions which remove reactive oxygen species such as peroxide:

2 GSH+ H2O2---------GSH-Px → GSSG + 2 H2O

Selenium also plays a role in the functioning of the thyroid gland by participating as a cofactor for the three known thyroid hormone deiodinases.[5]

Dietary selenium comes from nuts, cereals, meat, fish, and eggs. Brazil nuts are the richest ordinary dietary source (though this is soil-dependent, since the Brazil nut does not require high levels of the element for its own needs). High levels are found in meats such as kidney, crab and lobster, in that order.[6][7]


Although selenium is an essential trace element, it is toxic if taken in excess. Exceeding the Tolerable Upper Intake Level of 400 micrograms per day can lead to selenosis.[8] Symptoms of selenosis include a garlic odour on the breath, gastrointestinal disorders, hair loss, sloughing of nails, fatigue, irritability and neurological damage. Extreme cases of selenosis can result in cirrhosis of the liver, pulmonary edema and death.[9]

Elemental selenium and most metallic selenides have relatively low toxicities because of their low bioavailability. By contrast, selenate and selenite are very toxic, and have modes of action similar to that of arsenic. Hydrogen selenide is an extremely toxic, corrosive gas.[10] Selenium also occurs in organic compounds such as dimethyl selenide, selenomethionine, selenocysteine and methylselenocysteine, all of which have high bioavailability and are toxic in large doses. Nano-size selenium has equal efficacy, but much lower toxicity.[11][12][13][14][15][16][17]

Selenium poisoning of water systems may result whenever new agricultural runoff courses through normally dry undeveloped lands. This process leaches natural soluble selenium compounds (such as selenates) into the water, which may then be concentrated in new "wetlands" as the water evaporates. High selenium levels produced in this fashion have been found to have caused certain congenital disorders in wetland birds.[18]


Selenium deficiency is relatively rare in healthy well-nourished individuals. It can occur in patients with severely compromised intestinal function, or those undergoing total parenteral nutrition. Alternatively, people dependent on food grown from selenium-deficient soil are also at risk. In the USA, the Dietary Reference Intake for adults is 55 µg/day. In the UK it is 75 µg/day for adult males and 60 µg/day for adult females. 55 µg/day recommendation is based on full expression of plasma glutathione peroxidase. Selenoprotein P[19] is a better indicator of selenium nutritional status, and full expression of it would require more than 66 µg/day.[20]

Selenium deficiency can lead to Keshan disease, which is potentially fatal. Selenium deficiency also contributes (along with iodine deficiency) to Kashin-Beck disease.[21] The primary symptom of Keshan disease is myocardial necrosis, leading to weakening of the heart. Kashin-Beck disease results in atrophy, degeneration and necrosis of cartilage tissue.[22] Keshan disease also makes the body more susceptible to illness caused by other nutritional, biochemical, or infectious diseases. These diseases are most common in certain parts of China where the soil is extremely deficient in selenium. Studies in Jiangsu Province of China have indicated a reduction in the prevalence of these diseases by taking selenium supplements.

Selenium is also necessary for the conversion of the thyroid hormone thyroxine (T4) into its more active counterpart, triiodothyronine, and as such a deficiency can cause symptoms of hypothyroidism, including extreme fatigue, mental slowing, goitre, cretinism and recurrent miscarriage.[9]

Controversial health effects

Several studies have suggested a link between cancer and selenium deficiency.[23][24][25][26][27][28][29] A study conducted on the effect of selenium supplementation on the recurrence of skin cancers did not demonstrate a reduced rate of recurrence of skin cancers, but did show a significantly reduced occurrence of total cancers.[30] Dietary selenium prevents chemically induced carcinogenesis in many rodent studies.[31] In these studies, organic seleno-compounds are more potent and less toxic than selenium salts (e.g., selenocyanates, selenomethionine, selenium-rich Brazil nuts, or selenium-enriched garlic or broccoli). Selenium may help prevent cancer by acting as an antioxidant or by enhancing immune activity. Not all studies agree on the cancer-fighting effects of selenium. One study of naturally occurring levels of selenium in over 60,000 participants did not show a significant correlation between those levels and cancer.[32] The SU.VI.MAX study[33] concluded that low-dose supplementation (with 120 mg of ascorbic acid, 30 mg of vitamin E, 6 mg of beta carotene, 100 µg of selenium, and 20 mg of zinc) resulted in a 31% reduction in the incidence of cancer and a 37% reduction in all cause mortality in males, but did not get a significant result for females.[34] The SELECT study[35] is currently investigating the effect of selenium and vitamin E supplementation on incidence of prostate cancer. However, selenium has been proven to help chemotherapy treatment by enhancing the efficacy of the treatment, reducing the toxicity of chemotherapeutic drugs, and preventing the body's resistance to the drugs.[36] One of the studies[37] showed that in just 72 hours, the efficacy of treatment using chemotherapeutic drugs, such as Taxol and Adriamycin, with selenium yeast is significantly higher than the treatment using the drugs alone. The finding was shown in various cancer cells (breast, lung, small intestine, colon, liver).
Some research has indicated a geographical link between regions of selenium deficient soils and peak incidences of HIV/AIDS infection. For example, much of sub-Saharan Africa is low in selenium. However, Senegal is not, and also has a significantly lower level of AIDS infection than the rest of the continent. AIDS appears to involve a slow and progressive decline in levels of selenium in the body. Whether this decline in selenium levels is a direct result of the replication of HIV[38] or related more generally to the overall malabsorption of nutrients by AIDS patients remains debated.
Low selenium levels in AIDS patients have been directly correlated with decreased immune cell count and increased disease progression and risk of death.[39] Selenium normally acts as an antioxidant, so low levels of it may increase oxidative stress on the immune system leading to more rapid decline of the immune system. Others have argued that HIV encodes for the human selenoenzyme glutathione peroxidase, which depletes the victim's selenium levels. Depleted selenium levels in turn lead to a decline in CD4 helper T-cells, further weakening the immune system.[40]
Regardless of the cause of depleted selenium levels in AIDS patients, studies have shown that selenium deficiency does strongly correlate with the progression of the disease and the risk of death.[41][42][43] Selenium supplementation may help mitigate the symptoms of AIDS and reduce the risk of mortality. It should be emphasized that the evidence to date does not suggest that selenium can reduce the risk of infection or the rate of spread of AIDS, but rather treat the symptoms of those who are already infected.
A well-controlled study showed that selenium intake is positively correlated with the risk of developing type II diabetes. Because high serum selenium levels are positively associated with the prevalence of diabetes, and because selenium deficiency is rare, supplementation is not recommended in well-nourished populations such as the U.S.[44]

Biological applications

Medical use
The substance loosely called selenium sulfide, SeS2, actually selenium disulfide or selenium (IV) sulfide, is the active ingredient in some dandruff shampoos.[45] The effect of the active ingredient is to kill the scalp fungus Malassezia which causes shedding of dry skin fragments. The ingredient is also used in body lotions to treat Tinea versicolor due to infection by a different species of Malassezia fungus.[46]
Selenium is used widely in vitamin preparations and other dietary supplements, in small doses (typically 50 to 200 micrograms per day for adult humans). Some livestock feeds are fortified with selenium as well.



  5. Linus Pauling Institute at Oregon State University
  6. Barclay, Margaret N. I., Allan MacPherson, James Dixon (1995). Selenium content of a range of UK food. Journal of food composition and analysis 8: 307-318. 0889-1575.
  7. A list of selenium rich foods can be found on The Office of Dietary Supplements Selenium Fact Sheet.
  8. Dietary Supplement Fact Sheet: Selenium
  9. 9.0 9.1 DRAFT
  11. Zhang J, Wang X, Xu T (2008). Elemental selenium at nano size (Nano-Se) as a potential chemopreventive agent with reduced risk of selenium toxicity: comparison with se-methylselenocysteine in mice. Toxicol. Sci. 101 (1): 22–31.
  12. Gao X, Zhang J, Zhang L (2000). [Acute toxicity and bioavailability of nano red elemental selenium]. Wei Sheng Yan Jiu 29 (1): 57–8.
  13. Zhang JS, Gao XY, Zhang LD, Bao YP (2001). Biological effects of a nano red elemental selenium. Biofactors 15 (1): 27–38.
  14. Zhang J, Wang H, Yan X, Zhang L (2005). Comparison of short-term toxicity between Nano-Se and selenite in mice. Life Sci. 76 (10): 1099–109.
  15. Jia X, Li N, Chen J (2005). A subchronic toxicity study of elemental Nano-Se in Sprague-Dawley rats. Life Sci. 76 (17): 1989–2003.
  16. Wang H, Zhang J, Yu H (2007). Elemental selenium at nano size possesses lower toxicity without compromising the fundamental effect on selenoenzymes: comparison with selenomethionine in mice. Free Radic. Biol. Med. 42 (10): 1524–33.
  17. Peng D, Zhang J, Liu Q, Taylor EW (2007). Size effect of elemental selenium nanoparticles (Nano-Se) at supranutritional levels on selenium accumulation and glutathione S-transferase activity. J. Inorg. Biochem. 101 (10): 1457–63.
  19. Papp LV, Lu J, Holmgren A, Khanna KK (2007). From selenium to selenoproteins: synthesis, identity, and their role in human health. Antioxid. Redox Signal. 9 (7): 775–806.
  20. Xia Y, Hill KE, Byrne DW, Xu J, Burk RF (2005). Effectiveness of selenium supplements in a low-selenium area of China. Am. J. Clin. Nutr. 81 (4): 829–34.
  21. DRAFT
  22. NEJM - Kashin-Beck Osteoarthropathy in Rural Tibet in Relation to Selenium and Iodine Status
  23. Plasma selenium levels and the risk of colorectal ...[Nutr Cancer. 1997] - PubMed Result
  24. Naturally occurring selenium compounds in cancer c...[Cancer Epidemiol Biomarkers Prev. 1997] - PubMed Result
  25. Is low selenium status a risk factor for lung canc...[Am J Epidemiol. 1998] - PubMed Result
  26. Dietary selenium repletion may reduce cancer incid...[Nutr Rev. 1997] - PubMed Result
  27. The genotoxicity of selenium. [Mutat Res. 1985] - PubMed Result
  28. Intervention studies on cancer. [Eur J Cancer Prev. 1999] - PubMed Result
  29. Blood serum selenium in the province of Mérida, Ve...[J Trace Elem Electrolytes Health Dis. 1990] - PubMed Result
  30. Effects of selenium supplementation for cancer pre...[JAMA. 1996] - PubMed Result
  31. Chemoprevention Database
  32. Prospective study of toenail selenium levels and c...[J Natl Cancer Inst. 1995] - PubMed Result
  33. Background and rationale behind the SU.VI.MAX Stud...[Int J Vitam Nutr Res. 1998] - PubMed Result
  34. The SU.VI.MAX Study: a randomized, placebo-control...[Arch Intern Med. 2004] - PubMed Result
  35. Selenium and Vitamin E Cancer Prevention Trial (SELECT) Home Page
  36. Selenium and Chemotherapy - Nutrition Health
  37. Selenium Cancer 1 - Nutrition Health
  38. Nutrients and HIV: part one - beta carotene and s...[Altern Med Rev. 1999] - PubMed Result
  39. Dietary Supplement Fact Sheet: Selenium
  41. High risk of HIV-related mortality is associated w...[J Acquir Immune Defic Syndr Hum Retrovirol. 1997] - PubMed Result
  42. Mortality risk in selenium-deficient HIV-positive ...[J Acquir Immune Defic Syndr Hum Retrovirol. 1999] - PubMed Result
  43. Micronutrient status in relationship to mortality ...[Nutr Rev. 1998] - PubMed Result
  44. Serum Selenium and Diabetes in U.S. Adults - Bleys et al. 30 (4): 829 - Diabetes Care
  45. Accessed Dec. 25, 2007
  46. Selenium sulfide. DermNet NZ

External links

Template:Compact periodic table

This page uses Creative Commons Licensed content from Wikipedia (view authors).