Psychology Wiki
Brain: Septum pellucidum
The fornix and corpus callosum from below.
Latin '
Gray's subject #189 840
Part of
BrainInfo/UW hier-238
MeSH A08.

The septum pellucidum, also called the septum lucidum, is a thin, triangular, vertical membrane that, reaching down from the corpus callosum to the fornix, separates the lateral ventricles of the brain. It is part of the limbic system and is one of the pleasure centers of the brain. Electrical stimulation in humans results in sensations of well being. Rats having access to levers to control stimulation from electrodes implanted in this area, self stimulate themselves for long periods ignoring the requirements for food, sex and sleep.

Removal of the area ids associated with septal rage.

The septum pellucidum actually consists of two layers or laminae of both white and gray matter, called the laminae septi pellucidi. These layers are normally fused; however, in approximately one-tenths of humans, there is a slit-like cavity between them. This space is occasionally called the fifth ventricle, although is usually not continuous with the ventricular system and does not contain cerebrospinal fluid.

The septum pellucidum is located in the midline of the brain, between the two cerebral hemispheres. It is attached superiorly (above), anteriorly (in front), and inferiorly (below) to the corpus callosum, the large collection of nerve fibers that connect the two hemispheres. Inferiorly and posteriorly (in back), it is attached to the anterior part of the fornix. On either side are the two lateral ventricles, pockets of cerebrospinal fluid within the cerebral hemispheres.

Absence of the septum pellucidum or corpus callosum, caused by mutations in the HESX1 gene, is associated with septo-optic dysplasia. This may result in hypothalamic dysfunction and hypopituitarism, as well as problems of vision, coordination, and intelligence, among other abnormalities.


  • Gray, Henry & Clemente, Carmine D. (1984). Gray's Anatomy of the Human Body (30th ed.). New York: Lippincott Williams & Wilkins.
  • Kasper, Dennis L.; Braunwald, Eugene; Fauci, Anthony S.; Hauser, Stephen L.; Longo, Dan L.; Jameson, J. Larry; & Kurt J. Isselbacher, (Eds.) (2004). Harrison's Principles of Internal Medicine (16th ed.). New York: McGraw-Hill.

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