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Two-pore-domain potassium channels: This family of 15 members form what is known as "leak channels" which possess Goldman-Hodgkin-Katz (open) rectification.[1] These channels are regulated by several mechanisms including oxygen tension, pH, mechanical stretch, and G-proteins. Their name is derived from the fact that the α subunits consist of four transmembrane segments, each containing two pore loops. As such, they structurally correspond to two inward-rectifier α subunits and thus form dimers in the membrane.
Below is a list of the 15 known two-pore-domain human potassium channels:[1]
| Gene | Name |
| KCNK1 | K2p01.1 |
| KCNK2 | K2p02.1 |
| KCNK3 | K2p03.1 |
| KCNK4 | K2p04.1 |
| KCNK5 | K2p05.1 |
| KCNK6 | K2p06.1 |
| KCNK7 | K2p07.1 |
| KCNK9 | K2p09.1 |
| KCNK10 | K2p10.1 |
| KCNK12 | K2p12.1 |
| KCNK13 | K2p13.1 |
| KCNK15 | K2p15.1 |
| KCNK16 | K2p16.1 |
| KCNK17 | K2p17.1 |
| KCNK18 | K2p18.1 |
See also[]
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References[]
Membrane transport protein: ion channels
| |
|---|---|
| Ca | Voltage-dependent calcium channel (L-type/CACNA1C, N-type, P-type, Q-type, R-type, T-type) - Inositol triphosphate receptor - Ryanodine receptor - Cation channels of sperm |
| Na: Sodium channel | Nav1.4 - Nav1.5 - Nav1.7 - Epithelial sodium channel |
| K: Potassium channel | Voltage-gated (KvLQT1, KvLQT2, KvLQT3, HERG, Shaker gene, KCNE1) - Calcium-activated (BK channel, SK channel) - Inward-rectifier (ROMK, KCNJ2) - Tandem pore domain |
| Cl: Chloride channel | Cystic fibrosis transmembrane conductance regulator |
| Porin | Aquaporin (1, 2, 3, 4) |
| Transient receptor potential | TRPA - TRPC (TRPC6) - TRPM (TRPM6) - TRPML (Mucolipin-1) - TRPP - TRPV (TRPV1, TRPV6) |
| Other/general | Gap junction - Stretch-activated ion channel - Ligand-gated ion channel - Voltage-gated ion channel - Cyclic nucleotide-gated ion channel - Two-pore channel |
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