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|MRI cross-section of human brain, with thalamus marked.|
|Scheme showing the course of the fibers of the lemniscus; medial lemniscus in blue, lateral in red.|
|Gray's||subject #189 808|
The thalamus (from Greek θάλαμος = bedroom, chamber) is the main part of the diencephalon, a portion of the brain. In the caudal (tail) to oral (mouth) sequence of neuromeres, the diencephalon is located between the mesencephalon (cerebral peduncule, belonging to the brain stem) and the telencephalon. The diencephalon includes also the dorsally located epithalamus (essentially the habenula and annexes) and the perithalamus (prethalamus formerly described as ventral thalamus) containing the zona incerta and the "reticulate nucleus". Due to their different ontogenetic origins, the epithalamus and the perithalamus are formally distinguished from the thalamus proper.
This article essentially deals with the human thalamus and may differ in comparison with accounts in non-upper primate species. In normal humans, the two thalami are prominent bulb-shaped masses, about 5.7 cm in length, located obliquely (about 30°) and symmetrically on each side of the third ventricle. The two can adhere on a variable extent, in 30% of humans, through the adhesio interthalamica (or massa intermedia, with no interthalamic connection in our species).
The thalamus comprises a system of lamellae (made up of myelinated fibers) separating different thalamic subparts. Other areas are defined by distinct clusters of neurons, such as the periventricular gray, the intralaminar elements, the "nucleus limitans", and others. These latter structures, different in structure from the major part of the thalamus, have been grouped together into the allothalamus as opposed to the isothalamus (Percheron, 2003).
Please see also List of thalamic nuclei.
The isothalamus constitutes 90% or more of the thalamus, and despite the variety of functions it serves, follows a simple organizational scheme. The constituting neurons belong to two different neuronal genera. The first correspond to the thalamocortical neurons (or principal). They have a "tufted" morphology, as their dendritic arborisation is made up of straight dendritic distal branches starting from short and thick stems. The number of branches and the diameter of the arborisation are linked to the specific system of which they are a part, and to the animal species. They have the rather rare property of having no initial axonal collaterals, which implies that one emitting thalamocortical neuron does not send information to its neighbor. They send long-range glutamatergic projections to the cerebral cortex. The other genus is made up of "microneurons". These have short and thin dendrites and short axon(s) and thus belong to local circuitry neurons. Their percentage in comparison to thalamocortical neurons varies across species, highly increasing with evolution. Their short axonal parts contact thalamocortical or other local circuitry neurons. Their neurotransmitter is GABA. The dendrites of the two constituting genera receive synapses from a variety of afferent axons. The connection back to the thalamocortical neurons create "triads" modulating the thalamocortical output. One subcortical afference comes from the perithalamus ( reticulate nucleus). This receives axonal branches from thalamocortical neurons. Its afferences are also GABAergic. The number of perithalamic neurons strongly decreases in evolution in opposition to the large increase in microneurons (Arcelli et al. 1997). To some extent the perithalamus plays a role in the local circuitry. The circuitous connection with corticothalamic neurons participates in the elaboration of thalamic rhythms.
The different functional modalities represented in the thalamus are segregated in specific anatomical regions, differentiated by the cerebral systems from where they receive their afferent projections. There are more corticothalamic than thalamocortical axons. Corticothalamic endings are of two kinds. The "classical" projection emanates from layer VI of the cortex, is thin and has a long, almost straight, trajectory through the thalamus, not respecting intrathalamic borders. Its terminal synapses are glutamatergic. The second kind of corticothamic axon is the Rockland type II (1994). This emanates from large pyramidal cells and is much thicker. Its ending is small, dense and globular. Its synapses are located close to the soma of the thalamic neuron, often forming the center of glomerular complexes. The isothalamus serves the function of transforming and distributing "prethalamic" information to the cortex.
Isothalamic parts or regions
The thalamic parts delineated by the lamellar and cellular "limiting" elements, according to the founding system of Burdach (1822), constituted the classic thalamic nuclei. These have been later further subdivided. The Louvain symposium (in Dewulf, 1971)  made the recommendation to call the classical subdivisions "region". One region may be made up of one or several nuclei. These may have one (or several) pars, if there is a particular coafference for instance.
The region separated by the superior lamella is the Anterior region (A). The region separated medially by the medial lamina is the Lateral region (L). Almost separated from the thalamic mass are the Geniculate bodies (G). The remaining isothalamus is made up of the medial region (M, medial to the medial lamina) and posteriorly, with no complete separation in man, of the posterior regio or pulvinar (Pu). The last two represent a huge medioposterior ensemble. The classical separation into relay nuclei, receiving "specific" subcortical afferences or association nuclei, which would not, cannot be retained as absolute. The lateral region and the geniculate bodies indeed receive strong lower "specific" afferences and can be seen as the "sensorimotor" part of the thalamus. The medioposterior ensemble, in most of its volume does not receive subcortical afferents and abundant afferences from the "associative" cortex but in some, essentially ventral parts, in fact receives subcortical afferences, such as tectal, spinothalamic or amygdalar. The anterior region receives a particular afference that is not entirely subcortical (directly or indirectly from the subiculum).
Thalamic regions may be functionally inhomogeneous. The elements of the lateral region have been frequently separated into ventral and dorsal (in fact named lateral) nuclei. This subdivision no more hold true. Cytoarchitectonics have partly failed. What differentiates anatomofunctional parts are the major afferent systems present in the thalamus as terminal parts of axons and axonal arborisations. Three-dimensional analyses of the distribution of all the axonal ending coming from the same source show that they occupy together an own space in the thalamus, which is called a territory. Such a main territory do no mix or overlap in primates with neighbouring territories (Percheron et al. 1998). This is what made possible a solid partition of the thalamus. These territories may cover one or several nuclei. The analyses of the three-dimensional geometry of the main afferent terrirories in macaques have shown that a dorsal element on transverse sections is simply the posterior part of the preceding territory. There are thus no "dorsal nuclei". This is one reason why the nomenclature selected by the Nomina anatomica and the Terminologia anatomica (1998)  is hardly applicable. The evolution of the thalamus follows that of the cortex and there are differences including between primates (new world monkeys and old world; old world and humans), which means that a universal nomenclature valid in all species is not simply reachable.
Superior region S
The superior region comprises two elements that were linked during a long time and were later wrongly separated: the nucleus anterior and the nucleus superficialis, or superior (previous nucleus lateralis dorsalis). The nucleus anterior, divided into several entities in non-human species, is undivided in man. The two, anterior and superficial, nuclei are separated from the lateral and medial regions by the lamella superior and are everywhere surrounded by a capsule of white matter, including the lamina terminalis. The second nucleus (superficialis or superior) is posterior and in succession to the first. The two are constituted in the same manner. The main difference is their mode of afference. Both receives information from the subiculum of the hippocampus but in one case indirectly and in the other directly. The efferent axons of the subiculum follow the fornix. At the anterior part of the fornix, part of them go down to the mammillary body. The neurons of the mammillary bodies give axons forming the thick and dense mamillo-thalamic tract (of Vicq d'Azyr), which ends in the nucleus anterior. Another part of the subicular axons does not end in the mamillary body as, at the level of the foramen of Monro, they turn posteriorly. Some of them end into the anterior nucleus but a great quantity end in the nucleus superficialis. The selective target of the efferent axons from the anterior nucleus is the anterior cingulate cortex, that of the superfial nucleus is the posterior cingulate, with some overlap. The axons of these parts of the cingulate cortex, linked through the large cingulum (longitudinal bundle located at the base of the cingulate cortex), return to the parahippocampal gyrus. This circuit referred to as the Papez circuit (1937) was said by its author to be the substrate for emotion. There have been many further other elaborations (including the "limbic system"). Papez' circuit was in fact not close (at hippocampal level). In addition, the second nucleus, the superficial nucleus, not taken into consideration, has similar connections and participates in other close or linked circuits. The better known effect of the lesion of mamillary bodies, of the mamillothamic bundle and the fornix, if bilateral, is a particular (anterograde) amnesia (Korsakoff syndrom).
Medial region. Medial nucleus. M
The nucleus medialis corresponds to the part which is located medial to the lamina medialis. In the anterior part of the lamina, the oral intralaminar cellular part makes a clear border. This is no more true posteriorly with the pulvinar. Due to their constitution and connection, the two constitute a common set corresponding to the largest mass of the human thalamus. In non human primates, the medial nucleus (often named dorsomedian) is subdivided into several subnuclei. It is admitted that this is no longer the case in humans, which makes comparison even with old world monkeys difficult. Some subcortical afferences are documented in macaques (amygdalar, tectal). There are no arguments in favour of their existence in humans. The majority of the afferences comes from the cortex, reciprocated by corticothalamic efferences. In macaques, the spatial distribution of the connection was said to be "circunferential" (Goldman-Rakic and Porrino, 1985), medial cortical areas being linked to medial parts of the nucleus and lateral dorsal to lateral dorsal. This is also true in humans. The strong interrelation between the medial nucleus and the frontal cortex is known for long. Lobotomies were intended to cut this connection. There are however other mediocortical connections; with the cingulate cortex, the insular cortex and also with the premotor cortex.
Posterior region. Pulvinar. Pu
Pulvinar means pillow in Latin. It constitutes the posterior pole of the thalamus and its posterior border is indeed smooth. Anteriorly there is only an uncomplete boundary with the medial nucleus. The two have in fact common connections both thalamocortical and corticothalamic. This is the case for instance for the frontal cortex. The usual subdivisions do not fit with the distribution of cortical afferent. A main part receives flat islands of axonal terminations from the frontal, parietal, temporal and preoccipital cortex. Only one part of the pulvinar is particular, the intergeniculate or inferior pulvinar, which receives tectal afferents and which has a visuotopic map.
Basal region B
In the postero inferior part of the thalamus is a place which raises not solved problems. This is a place of endings of spinothalamic terminal axonal arborisations. The spinothalamic tracts ends in three "lateral elements", the VCP , VCO, and VIm. Secondly, it ends, close to these, in intralaminar-limitans elements. The third place of ending, the basal formation (not a classical nucleus, in a place that was attributed to lower pulvinar), is particular only in one place named the nucleus basalis nodalis that was claimed by some to be the only relay of pain messages from layer I of the spinal cord. This place has been shown to send axons to the insula. In fact VCP also conveys painful stimuli.
Geniculate region. G
This is made up of the two "geniculate bodies" (knee-form bodies) that are located ventrally at the surface of the thalamus, below the pulvinar. They are "relays" of highly specific functions: audition for the first and vision for the second. They differentiate early in ontogenesis and totally, for the lateral or partially for the medial separate from the thalamic mass. They are however specialized but authentical isothalamic elements.
Medial geniculate nucleus GM
The nucleus geniculatus medialis receives axons from auditory axons. From the cochlea, peripheral auditory information goes to the cochlear nucleus. From there, through the cochlear nerve, axons reach the superior olivary complex of both sides. Axons from there constitute the lateral lemniscus which ends in the inferior colliculus. Axons from the inferior colliculus constitute the brachium of the inferior colliculus and end in the medial geniculate. The thalamocortical axons from the medial geniculate nucleus end in the primary auditory cortex located in the center of the superior temporal plane. See auditory system.
Lateral geniculate nucleus GL
The nucleus geniculatus lateralis is made up of different cellular strata separated by lamellae, parallel to the surface. The stratae 1 and 2, the most ventral, are magnocellular. The other are mediocellular. From the retina, the axons of the optic nerves go directly to the geniculate nuclei. The nasal component of the optic nerves (the axons issued from the nasal field of the retina of both sides) crosses at the chiasma.The axons of the temporal field do not cross. This is very important in clinical neurology. After the chiasma, axons form the visual tracts turning around the peduncles and arriving int the polar anterior part of the geniculate nucleus. Retinal axons from the controlateral retina end in stratae 1,4 and 6. Those from the ipsilateral retina end in 2,3 and 5. The axons from the lateral geniculate nucleus, through the optic radiation, end in the primary visual cortex around the calcarine fissure. See visual system.
Lateral region L (or V)
This corresponds to the part of isothalamus located laterally to the medial lamina and in front of the pulvinar (the noyau externe of Dejerine after Burdach). It receives abundant and diverse infrathalamic afferences. Some main afferent systems occupy a particular portion in the lateral region. Several "main territories" are spatially separate. This allows functionnally significant subdivisions. Other afferent systems may end in one or the other main territories to which they are coterritories. Still other can end in several main territories. The topographic description of the territories was made using experiments in monkeys. This showed that they are no dorsal nuclei. What was believed to be dorsal was simply the posterior extension of the more anterior territory. This makes it difficult to follow the Terminologia anatomica (1998). To follow common usage, lateral nuclei are called "ventral". It is today possible to transfer the data experimentally obtained in monkeys to the human brain using immunostaining. The sequence described by C. Vogt (1909) hold true. Starting from caudally one may describe the lemniscal territory, made up of two components cutaneous or tactile and deep (musculoarticular), the cerebellar territory also made up of two nuclei, the pallidal territory and the nigral territory .
Gustatory territory VArc
Tied to VCM into the classic arcuate nucleus (in fact heterogeneous), it has neurons of a own type. Also, it does not receive lemniscal afferent and is thus not a part of VC. It receives axons from the nucleus of the solitary tract. Its thalamocortical neurons send axons to the primary gustatory area located in the opercule of the insula.(see gustatory system)
Tactile lemniscal territory VPC=VPL+VPM
The nuclei corresponding to the lemniscal territory are called VP. The tactile part nucleus ventralis posterior caudal VPC is the posterior part of the lateral region, in front of the pulvinar. It is the addition of a lateral nucleus VPL and of the superior part of the classic arcuate nucleus VPM. VPC receives axons from the dorsal column nuclei located in the lower medulla oblongata: the nucleus gracilis (Goll) medial and the nucleus cuneatus (Burdach) lateral. Starting from these nuclei, axons go ventralwards and decussate (to the other side) still in the medulla forming the "lemniscal decussation". Axons from the two sides form the thick medial lemniscus close to the midline. Higher, it separates in order to reach the lower border of the two VPC. In this nucleus, the axons terminate forming lamellae and a somatotopical map. The axons conveying information from the leg are the most lateral and the most dorsal. Those conveying information from the mouth and tongue are the most medial and ventral (in VPM). The axonal arborisations are rather small and very dense. The mediator of the lemniscus system is glutamate. The thalamocortical axons of the VPC send their axons to the primary somatosensory area (areas 3b and 1) where there is also a clear somatotopic map.
Deep lemniscal territory VPO (or VPS)
Within the somesthetic nucleus, physiological maps, including in humans, have found a spatial separation between the representation of the tactile and the deep stimuli. Friedman and Jones (1986) designated the deep region the "shell" as opposed to the tactile "core". Kaas et al. (1986)  initially retained one VPO and one VPS. The present nucleus ventralis posterior oralis VPO is the addition of the two. This, made up very large neurons,the largest of the thalamus, is located in front and superior to the VPC. It receives axons from the accessory cuneate nucleus of the medulla. The axons of this nucleus conveys information from muscles, tendons and joints. They decussate and participate in the formation of the medial lemniscus. The VPO which receives "deep" information has about the same somatotopic map as the tactile. The thalamocortical neurons from VPO send their axons in the fundic area 3a (in the depth of the Rolando sulcus) and to the parietal area 5.
Cerebellar territory VIm or VL
The nucleus ventralis intermedius receives through the brachium conjunctivum axons from all cerebellar nuclei, more particularly from the dentate nucleus (Percheron, 1977, Asanuma et al. 1983). The mediator is glutamate. In primates, the dentate nucleus is subdivided into two nuclei: one anterior and the other posteroventral, the first "motor" and the other not (Dum and Strick, 2002). VIm is in fact made up of two parts, one ventrolateral (VImL) and one dorsomedian (VImM). VImL (the VIm of neurosurgeons) receives electively sensorimotor information. VImL also receives axons from the vestibulum and from the spinothalamic tract. It is organized according to a somatotopic map grossly analoguous to that of VPC. The cortical target of the VImL thalamocortical neurons is principally the primary motor cortex (prerolandic) (Schell and Strick, 1984, Orioli and Strick, 1989) . VImM receives mainly "associative" information from the dentate, plus tectal and spinothalamic information. It is organized according to another map, looser than that of VImL. Its thalamocortical neurons send their axons to the premotor and to the parietal cortex. As it was not clearly distinguished, there are poor physiological data.
Pallidal territory VO
Starting from cercopithecidae, the two sources from the basal ganglia system medial pallidum and nigra have distinct, spatially separate, thalamic territories. The pallidal territory arrives in evolution as a lateral addition to the nigal VA, forming a new nucleus individualized by another name : the nucleus ventralis oralis, VO. On the contrary there is no more VM (which receices convergent afferences in rodents and carnivora). VO receives its pallidal afferent axons from the medial pallidum. The trajectory of pallidal afferent axons is complex. Axons form first the ansa lenticularis and the fasciculus lenticularis which place the axons on the medial border of the pallidum. From there, the axons cross the internal capsule as the comb system. Axons arrives at the lateral border of the subthalamic nucleus. They pass over it as the H2 field of Forel (1877) then turn down at H and suddenly go up in H1 in direction to the inferior border of the thalamus. The distribution of pallidal axons within the territory is wide with terminal "bunches" (Arrechi-Bouchhioua et al. 1996,1997, Parent and Parent, 2004 ) . This offers few chance for a fine somatotopic organization. The territory is stained for calbindin. The mediator of the pallido-thalamic connection is the inhibitor GABA. The thalamocortical neurons send their axons to the supplementary motor area (SMA), preSMA, the premotordorsal and medial and to a lesser extend to the motor cortex.
Nigral territory VA
The nigral afferences come from the pars reticulata of the nigra. The axons do not constitute a conspicuous bundle. They are placed medially to the pallidal and ascend almost vertically. A part of the territory is posterior and inferior going up to the anterior pole of the central complex. This part sometimes designated as VM is simply the posterior continuation of the nigral territory. There is indeed no more VM in the upper primates where the pallidal and nigral territories are everywhere separated. In the whole territory axons expand widely (François et al. 2002) allowing no precise map , which is confirmed by physiology (Wichemann and Kliem, 2004). VA is crossed by the mammillothalamic bundle. The mediator of the nigro-thalamic connection is, as for the pallido-thalamic the inhibitor GABA. In addition to nigral, VA receives amygdalar and tectal (superior colliculus)axons. The thalamo-cortical axons go to the frontal cortex, the cingulate cortex, the premotor cortex and the oculomotor fields FEF and SEF.It is important to stress the necessity from now to clearly distinguish the pallidal VO and the nigral VA territories. The fact that they do not lead to the same cortical areas and systems is alone one reason for this. The physiology of the two territories is also different (van Donkelaar et al. (1999)
This or periventricular formation lies along the wall of the third ventricle. In man where there is no or almost no adhesio interthalamica this is reduced to a thin layer medial to the medial nucleus. There is no clear subdivisions and the formation may be seen as one entity. Contrarily to the isothalamus it stains for numerous mediators. Its connections are not really know, participating in periventricular systems.
Intralaminar-limitans formation Il-Li
This does not include the central region (see below). Along with the paramedian formation, it makes a kind of capsule around the medial nucleus ("circular nucleus"). Together they are deeply regressive structures in evolution. Only its anterior part is clearly present in humans. Caudally, dorsal to the central region it breaks in small islands. Some of them are just posterior to the complex. In the part dorsal to the complex, the aspect is deeply different from what is seen in macaques where "intralaminar" elements receive particular afferents such as cerebellar and tectal. The tectal afferents observed in macaques for instance have probably moved to the lateral region in humans, in VImM and VA. In any case the connections demonstrated in macaques cannot be assessed simply. The regression of intralaminar elements is to be contrasted with the huge increase of the cerebral cortex in man to ponderate the role of the intralaminar formation into the unspecific activation of the cortex. The nucleus limitans appears with primates. It borders the lower border of the pulvinar. Along with intralaminar islands, it receives spinothalamic afferences. Having the same properties, it is linked to them in the intralaminar-limitans formation. The posterior part receives axons from the spinothalamic fascicle and from the tectum. It sends its axons to the striatum constituting in man only a weak part of the thalamo-striatal connection.
Central region C
This corresponds to the "centre médian -parafascicular complex". Considering its ontogenesis, position, structure and connections, it does not belong, as usually said, to the intralaminar group. It is almost everywhere surrounded by a capsule. Dorsally this is made by a ventral extension of the lamina medialis but laterally, this is made by the lamina centralis separating it from the lateral region. In upper primates, the region or complex is not constituted by two but by three nuclei with their own neuronal species (Fenelon et al.1994) . From there, two opposed interpretations were proposed concerning the belonging of the intermediate part: either to the centre médian (the Vogts, 1941) or to the parafascicular nucleus (Niimi et al. 1960). This is undecidable. It has thus been proposed to group the three elements together in the regio Centralis (since it is a classical nucleus). From medially to laterally, one describes the pars parafascicularis, the pars media and the pars paralateralis. The first two strongly stain for acetylcholinesterase. They have strong connections with elements of the basal ganglia system. The pars parafascicularis is linked bilaterally to the substantia nigra. It receives in addition axons from the superior colliculus. Its sends axons to the associative striatum. The pars media receives a major connection from the medial pallidum. It also receives axons from the motor and premotor cortex. Its major efference is to the striatum (sensorimotor territory) (Fenelon et al. 1991). It is one element of the Nauta-Mehler's circuit (striatum-pallidum-pars media-striatum). The two medial elements are the main contributors to the thalamo-striatal connection. Their mediator is glutamate. The third, most lateral part (paralateral) receives from and sends axons to the central cortex, motor and premotor. The central region thus appears not as a nonspecific part of the thalamus but as one element of the basal ganglia system: one of its regulators. see Primate basal ganglia system.
The thalamus derives its blood supply from a number of arteries including polar and paramedian arteries, inferolateral (thalamogeniculate) arteries, and posterior (medial and lateral) choroidal arteries. These are all branches of the posterior cerebral artery.
The thalamus is known to have multiple functions. Deduced from the design of the isothalamus, it is generally believed to act as a translator for which various "prethalamic" inputs are processed into a form readable by the cortex. The thalamus is believed to relay information selectively to various parts of the cortex, as one thalamic point may reach one or several regions in the cortex. The thalamus also plays an important role in regulating states of sleep and wakefulness. Thalamic nuclei have strong reciprocal connections with the cerebral cortex, forming thalamo-cortico-thalamic circuits that are believed to be involved with consciousness. The thalamus plays a major role in regulating arousal, the level of awareness and activity. An animal with a severely damaged or severed thalamus suffers permanent coma. Many different functions are linked to the system to which thalamic parts belong. This is at first the case for sensory systems (which excepts the olfactory function) :auditory, somatic, visceral, gustatory and visual systems where localised lesions provoke particular sensory deficits. A major role of the thalamus is devoted to "motor" systems. This has been and continues to be a subject of interest for investigators. VIm, the relay of cerebellar afferences, is the target of stereotactians particularly for the improvement of tremor. The role of the thalamus in the more anterior pallidal and nigral territories in the basal ganglia system disturbances is recognized but still poorly known. The contribution of the thalamus to vestibular or to tectal functions is almost ignored. The thalamus has been thought of as a "relay" that simply forwards signals to the cerebral cortex. Newer research suggests that thalamic function is more complicated .
Cerebrovascular accidents (strokes) can cause thalamic syndrome (Dejerine and Roussy, 1906), which results in a contralateral hemianaesthesia, burning or aching sensation on one half of a body (painful anaesthesia)(like acid burns or peeling of flesh from the skin), often accompanied by mood swings. Ischaemia of the territory of the paramedian artery, if bilateral, causes serious troubles including akinetic mutism accompanied or not by oculomotor troubles. Korsakoff's Syndrome, stems from mammillary bodies, mammilothalamic, or thalamic lesions.
The ZLI is a transverse boundary located between the perithalamus and the functional distinct thalamus. Besides its morphological characteristics, it bears the hallmarks of a signalling centre. Fate mapping experiments in chicks have shown that the ZLI is cell lineage restricted at its boundaries and therefore can be termed a true developmental compartment in the forebrain.
Besides morphological characteristics, the ZLI is the only structure in the alar plate of the neural tube that expresses signaling molecules.
Studies in chicks have shown that Shh is both necessary and sufficient for thalamic gene induction.
In zebrafish, it was shown that the expression of two Shh genes, shh-a and shh-b (formerly described as twhh) mark the ZLI territory, and that Shh signaling is sufficient for the molecular differentiation of both the prethalamus and the thalamus but is not required for their maintenance and Shh signaling from the ZLI/alar plate is sufficient for the maturation of prethalamic and thalamic territory while ventral Shh signals are dispensable.
- Geniculate bodies (thalamus)
- Regions in the human brain
- List of thalamic nuclei
- Matrix-Core theory of thalamic organization
- Primate basal ganglia system
- Thalamus (non primate)
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Kuhlenbeck, H. (1937). The ontogenetic development of diencephalic centres in the bird's brain (chick) and comparison with the reptilian and mammalian diencephalon. J. Comp. Neurol. 66
Shimamura, K., Hartigan, D. J., Martinez, S., Puelles, L. and Rubenstein, J. L. (1995). Longitudinal organization of the anterior neural plate and neural tube. Development 121,3923 -3933.
Zeltser, L. M., Larsen, C. W. and Lumsden, A. (2001). A new developmental compartment in the forebrain regulated by Lunatic fringe. Nat. Neurosci. 4, 683-684.
Puelles, L. and Rubenstein, J. L. (2003). Forebrain gene expression domains and the evolving prosomeric model. Trends Neurosci. 26,469 -476.
Ishibashi, M. and McMahon, A. P. (2002). A sonic hedgehog-dependent signalling relay regulates growth of diencephalic and mesencephalic primordia in the early mouse embryo. Development 129,4807 -4819.
Kiecker, C. and Lumsden, A. (2004). Hedgehog signalling from the ZLI regulates diencephalic regional identity. Nat. Neurosci. 7,1242 -1249.
Scholpp S, Wolf O, Brand M, Lumsden A. Hedgehog signalling from the zona limitans intrathalamica orchestrates patterning of the zebrafish diencephalon'. Development. 2006 Mar;133(5):855-64
Human brain: diencephalon (TA A14.1.08, GA 9.807)
Hypothalamic sulcus · Tela chorioidea of third ventricle
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