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Brain: Tuber cinereum
Base of brain (Tuber cinerum visible at center).
Latin Tuber cinereum
Gray's subject #189 813
Part of
BrainInfo/UW hier-376
MeSH A08.186.211.730.385.357.352.870

The tuber cinereum is a hollow eminence of gray matter situated between the mammillary bodies and the optic chiasm. The tuber cinereum is part of the hypothalamus.


Laterally it is continuous with the anterior perforated substances and anteriorly with a thin lamina, the lamina terminalis.

The infundibulum, a hollow conical process, projects from the tuber cinereum. The infundibulum extends forward and down where it is attached to the posterior lobe of the pituitary gland.

It houses the nuclei:

  • tuberal nucleus
  • tuberomamillary nucleus [1]

Tuberomamillary nucleus

Main article: Tuberomamillary nucleus

The tuberomammillary nucleus (TMN) is the sole source of histamine in the brain. [2]


Circadian rhythm

Main article: Histamine H1_receptor#Neurophysiology

By its release of histamine, the tuberomamillary nucleus of the tuber cinereum helps to regulate the circadian cycle.

Additional images

See also


This article was originally based on an entry from a public domain edition of Gray's Anatomy. As such, some of the information contained herein may be outdated. Please edit the article if this is the case, and feel free to remove this notice when it is no longer relevant.

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