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| two pore segment channel 1 | |
|---|---|
| Symbol(s): | TPCN1 |
| Locus: | 12 q24.21 |
| EC number | [1] |
| EntrezGene | 53373 |
| OMIM | 609666 |
| RefSeq | NM_017901 |
| UniProt | Q9ULQ1 |
| two pore segment channel 2 | |
|---|---|
| Symbol(s): | TPCN2 |
| Locus: | 11 q13.1 |
| EC number | [2] |
| EntrezGene | 219931 |
| OMIM | [3] |
| RefSeq | NM_139075 |
| UniProt | Q8NHX9 |
Two-pore channels: This small family of 2 members putatively forms cation-selective ion channels. They are predicted to contain two KV-style six-transmembrane domains, suggesting they form a dimer in the membrane. These channels are related to catsper channels channels and, more distantly, TRP channels.
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Membrane transport protein: ion channels
| |
|---|---|
| Ca | Voltage-dependent calcium channel (L-type/CACNA1C, N-type, P-type, Q-type, R-type, T-type) - Inositol triphosphate receptor - Ryanodine receptor - Cation channels of sperm |
| Na: Sodium channel | Nav1.4 - Nav1.5 - Nav1.7 - Epithelial sodium channel |
| K: Potassium channel | Voltage-gated (KvLQT1, KvLQT2, KvLQT3, HERG, Shaker gene, KCNE1) - Calcium-activated (BK channel, SK channel) - Inward-rectifier (ROMK, KCNJ2) - Tandem pore domain |
| Cl: Chloride channel | Cystic fibrosis transmembrane conductance regulator |
| Porin | Aquaporin (1, 2, 3, 4) |
| Transient receptor potential | TRPA - TRPC (TRPC6) - TRPM (TRPM6) - TRPML (Mucolipin-1) - TRPP - TRPV (TRPV1, TRPV6) |
| Other/general | Gap junction - Stretch-activated ion channel - Ligand-gated ion channel - Voltage-gated ion channel - Cyclic nucleotide-gated ion channel - Two-pore channel |
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