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Weber's syndrome.svg|
ICD-10 | G463 | |
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ICD-9 | 344.89 | |
OMIM | [1] | |
DiseasesDB | 31247 | |
MedlinePlus | [2] | |
eMedicine | / | |
MeSH | {{{MeshNumber}}} |
Weber's syndrome (superior alternating hemiplegia) is a form of stroke characterized by the presence of an oculomotor nerve palsy and contralateral hemiparesis or hemiplegia.
Cause and presentation[]
This lesion is usually unilateral and affects several structures in the midbrain including:
Structure damaged | Effect |
---|---|
substantia nigra | contralateral parkinsonism because its dopaminergic projections to the basal ganglia innervate the ipsilateral hemisphere motor field, leading to a movement disorder of the contralateral body. |
corticospinal fibers | contralateral hemiparesis and typical upper motor neuron findings. It is contralateral because it occurs before the decussation in the medulla. |
corticobulbar tract | difficulty with contralateral lower facial muscles and hypoglossal nerve functions |
oculomotor nerve fibers | ipsilateral oculomotor nerve palsy with a drooping eyelid and fixed wide pupil pointed down and out. This leads to diplopia |
It is caused by midbrain infarction as a result of occlusion of the paramedian branches of the posterior cerebral artery or of basilar bifurcation perforating arteries.[1]
History[]
It carries the name of Sir Hermann David Weber, a German-born physician working in London, who described the condition in 1863.[2][3] It is unrelated to Sturge-Weber syndrome or Klippel-Trenaunay-Weber syndrome.
References[]
- ↑ GPnotebook -932511721
- ↑ Weber HD (1863). A contribution to the pathology of the crura cerebri. Medico-Chirurgical Transactions 46: 121–139.
- ↑ Template:Whonamedit
External links[]
CNS disease, Vascular disease: Cerebrovascular diseases (G45–G46 and I60–I69, 430–438) | |||||||||
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Brain ischemia/ cerebral infarction (ischemic stroke/TIA) |
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Intracranial hemorrhage (hemorrhagic stroke) |
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Aneurysm |
Cerebral aneurysm (Intracranial berry aneurysm, Charcot-Bouchard aneurysm) | ||||||||
Other/general |
Cerebral vasculitis | ||||||||
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Lesions of spinal cord and brain | |||||||||||
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Spinal cord/vascular myelopathy |
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Brainstem |
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Cerebellum |
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Basal ganglia | |||||||||||
Cortex |
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Thalamus | |||||||||||
Other |
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